History of Neocide 3 -

   Approximately 5 years ago, the Emerging Diseases Research
   Group at the University of Georgia College of Veterinary Medicine
   began working on a method to resolve multi-drug resistant bacterial
   infections in human burn patients. This research lead to the

   formulation of a potentiating agent that makes otherwise resistant
   bacteria susceptible to low class antibiotics. The potentiator that
   has proven effective against the "super" bugs that infect burns is
   also effective against the common bacteria associated with topical
   infections in Koi.

   To date, we found Neocide 3 to be beneficial in treating superficial
   infections in animals maintained in both experimental and field
   conditions. Among the advantages of Neocide are it's ease of use,
   safety, and applicability with a wide-variety of antibiotics and
   effectiveness against gram-positive and gram-negative bacterial
   pathogens.

   Neocide 3 has a rather interesting mode of activity that facilitates
   its spectrum of activity. Neocide creates holes in the bacterial cell
   wall which in-turn allows antibiotics to flood the organism, destroys
   the effectiveness of the bacteria's efflux pump and facilitates
   osmotic collapse of the bacterium. Because the potentiator
   causes direct physical damage to the bacteria, on is able to:

   [+] Kill otherwise drug-resistant bacteria with low class antibiotics
   [+] Use less antibiotic than would normally be necessary
   [+] Stimulate wound healing
   [+] Reduce the likelihood that exposed bacteria will develop
        resistance to the chosen antibiotic

   The latter fact is particularly important in aquaculture facilities
   use of antibiotics without Neocide 3 can quickly result in
   development of populations of bacteria that are resistant to
   many readily available antibiotics.

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   Results in the photographs above are
   from a series of standard 5 minute
   immersion baths over the period of
   about two weeks.

   [Top]
   Normal intact cell wall before exposure.
   [Bottom]
   Neocide induced Cytoplasmic leakage.

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